Comparative nucleotide sequences at the 3′ end of the neuraminidase gene from eleven influenza type A viruses
Identifieur interne : 002823 ( Main/Exploration ); précédent : 002822; suivant : 002824Comparative nucleotide sequences at the 3′ end of the neuraminidase gene from eleven influenza type A viruses
Auteurs : J. Blok [Australie] ; G. M. Air [Australie]Source :
- Virology [ 0042-6822 ] ; 1980.
English descriptors
- Teeft :
- Academic press, Amino, Amino acid, Amino acid sequence, Amino acid sequences, Amino acids, Antigenic, Antigenic drift, Antigenic variation, Base changes, Cdna, Cdna synthesis, Codon, Dideoxy method, Drift strains, Extra bands, Hemagglutinin, Influenza, Influenza virus, Influenza virus strains, Influenza viruses, Initiation codon, Laver, Leader sequence, Neuraminidase, Neuraminidase gene, Neuraminidase genes, Neuraminidase protein, Nucleotide, Nucleotide differences, Nucleotide sequence coding, Peptide, Polyacrylamide, Primer, Sanger, Schild, Sequence data, Sequencing, Subtypes, Synthetic dodecamer, Viral.
Abstract
Abstract: Neuraminidase genes, RNA segment 6, from six N1 and five N2 influenza A strains have been sequenced from the 3′ end of the viral RNA using the dideoxy method. In the first 200 nucleotides, 20 single base changes occur within the N1 subtype and 26 among the strains of the N2 subtype. Major differences were found between the sequences of the two subtypes (N1 and N2) where only about 100 of the first 200 nucleotides are the same. However, there is a region at the N terminus of the predicted amino acid sequence which is conserved between the N1 and N2 strains. The first 12 amino acids are identical in 9 of the 11 strains, and in the remaining two strains only a single amino acid substitution occurs.
Url:
DOI: 10.1016/0042-6822(80)90271-8
Affiliations:
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Blok</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra City, Australian Capital Territory 2601</wicri:regionArea><wicri:noRegion>Australian Capital Territory 2601</wicri:noRegion></affiliation></author><author><name sortKey="Air, G M" sort="Air, G M" uniqKey="Air G" first="G. M." last="Air">G. M. Air</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra City, Australian Capital Territory 2601</wicri:regionArea><wicri:noRegion>Australian Capital Territory 2601</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">107</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Amino</term><term>Amino acid</term><term>Amino acid sequence</term><term>Amino acid sequences</term><term>Amino acids</term><term>Antigenic</term><term>Antigenic drift</term><term>Antigenic variation</term><term>Base changes</term><term>Cdna</term><term>Cdna synthesis</term><term>Codon</term><term>Dideoxy method</term><term>Drift strains</term><term>Extra bands</term><term>Hemagglutinin</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus strains</term><term>Influenza viruses</term><term>Initiation codon</term><term>Laver</term><term>Leader sequence</term><term>Neuraminidase</term><term>Neuraminidase gene</term><term>Neuraminidase genes</term><term>Neuraminidase protein</term><term>Nucleotide</term><term>Nucleotide differences</term><term>Nucleotide sequence coding</term><term>Peptide</term><term>Polyacrylamide</term><term>Primer</term><term>Sanger</term><term>Schild</term><term>Sequence data</term><term>Sequencing</term><term>Subtypes</term><term>Synthetic dodecamer</term><term>Viral</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Neuraminidase genes, RNA segment 6, from six N1 and five N2 influenza A strains have been sequenced from the 3′ end of the viral RNA using the dideoxy method. In the first 200 nucleotides, 20 single base changes occur within the N1 subtype and 26 among the strains of the N2 subtype. Major differences were found between the sequences of the two subtypes (N1 and N2) where only about 100 of the first 200 nucleotides are the same. However, there is a region at the N terminus of the predicted amino acid sequence which is conserved between the N1 and N2 strains. The first 12 amino acids are identical in 9 of the 11 strains, and in the remaining two strains only a single amino acid substitution occurs.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Blok, J" sort="Blok, J" uniqKey="Blok J" first="J." last="Blok">J. Blok</name></noRegion><name sortKey="Air, G M" sort="Air, G M" uniqKey="Air G" first="G. M." last="Air">G. M. Air</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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